The overarching theme of the research in our group is the understanding of the information encoded in genomic sequences, and how this information is processed in the pathway leading from DNA to protein sequences. We are intrigued by the parallelism between computation and the processing of information encoded in biological sequences. The bulk of ouf research currently focuses on the mechanisms underlying RNA production (transcription) and post-processing (splicing), and it is increasingly incorporating high throughput and experimental approaches. We have recently became interested in the investigation of endophenotyes, specifically histopathological images, and we are developing computational methods to related histological features to cellular and molecular phenoytpes (mostly single-cell and bulk tissue transcriptomics) and to organismic phenotypes (i.e. diseases).