CO2MICS Lab
OverviewSpace: Independent Teams
SEEK ID: https://workflowhub.eu/projects/58
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Team created: 14th Sep 2021
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Teams: CO2MICS Lab
Organizations: Biomedical Research Foundation (BRFAA) of the Academy of Athens
https://orcid.org/0000-0003-2078-0844
Teams: CO2MICS Lab
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Analysis of RNA-seq data starting from BAM and focusing on mRNA, lncRNA and miRNA
DownloadThis workflow is based on the idea of comparing different gene sets through their semantic interpretation. In many cases, the user studies a specific phenotype (e.g. disease) by analyzing lists of genes resulting from different samples or patients. Their pathway analysis could result in different semantic networks, revealing mechanistic and phenotypic divergence between these gene sets. The workflow of BioTranslator Comparative Analysis compares quantitatively the outputs of pathway analysis, ...
BioTranslator performs sequentially pathway analysis and gene prioritization: A specific operator is executed for each task to translate the input gene set into semantic terms and pinpoint the pivotal-role genes on the derived semantic network. The output consists of the set of statistically significant semantic terms and the associated hub genes (the gene signature), prioritized according to their involvement in the underlying semantic topology.
