BioTranslator Workflow
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Run on GalaxyBioTranslator performs sequentially pathway analysis and gene prioritization: A specific operator is executed for each task to translate the input gene set into semantic terms and pinpoint the pivotal-role genes on the derived semantic network. The output consists of the set of statistically significant semantic terms and the associated hub genes (the gene signature), prioritized according to their involvement in the underlying semantic topology.
Inputs
| ID | Name | Description | Type |
|---|---|---|---|
| Input Gene List | Input Gene List | The input gene set (gene symbols or ensembl gene ids) in 'txt' format. |
|
Steps
| ID | Name | Description |
|---|---|---|
| 1 | Execution of BioTranslator | The algorithm consists of two sequential tasks: 1. Pathway Analysis, using the selected ontology 2. Gene Prioritization on the derived network of the enriched terms Outputs: 1. The enriched terms 2. The highly prioritized input genes 3. A heatmap which illustrates the association between prioritized genes and semantic clusters biotranslator_lite |
Outputs
| ID | Name | Description | Type |
|---|---|---|---|
| GO Enriched Terms | GO Enriched Terms | n/a |
|
| GO Gene Prioritization | GO Gene Prioritization | n/a |
|
| GO Heatmap | GO Heatmap | n/a |
|
Version History
Version 1 (earliest) Created 15th Sep 2021 at 18:27 by thodk
Added/updated 2 files
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Creators and SubmitterViews: 5546 Downloads: 666 Runs: 1
Created: 15th Sep 2021 at 18:27
Last updated: 24th Sep 2021 at 16:16
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Teams: CO2MICS Lab
Organizations: Biomedical Research Foundation (BRFAA) of the Academy of Athens
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