Workflow Type: KNIME
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This workflow can be used to fit dose-response curves from normalised biochemical assay data (%Inhibition) using the HCS extension. This workflow needs R-Server to run in the back-end. Start R and run the following command: library(Rserve); Rserve(args = "--vanilla") IC50 values will not be extrapolated outside the tested concentration range For activity classification the following criteria are applied:
- maximum (average % inhibion) >25 % and slope is >0 and IC50 > 5 µM or
- minimum (average % inhibion) >75 % Results are formatted for upload to the European Chemical Biology Database (ECBD)
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Version 1 (earliest) Created 26th Sep 2022 at 11:15 by Jeanette Reinshagen
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Created: 26th Sep 2022 at 11:15
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